Sure you can
You would have find mesh object in your model. That contain vertex and index buffer. You can even create your fresh new model in runtime
http://docs.unity3d.com/ScriptReference/Mesh.html
If you don't want to instantiate you could use Resources.Load you would get asset object. But for loading things in runtime you need to put file you want to be loaded in folder named Resources
Most of asset type in unity 5 let you read, manipulate and generate anything at runtime if you could understand the engine. Not an easy task but not so difficult. Have fun
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